The boycott will take place across a full fixture program in the men's and women's professional game from 3 p.m. local time (1400 GMT) on Friday to 11:59 p.m. on Monday May 3.
Clubs across the Premier League, English Football League, Women's Super League and Women's Championship will switch off their Facebook, Twitter and Instagram accounts to emphasize that social media companies must do more to eradicate online hate.
"Racist behavior of any form is unacceptable and the appalling abuse we are seeing players receive on social media platforms cannot be allowed to continue," Premier League CEO Richard Masters said in a statement.
"The Premier League and our clubs stand alongside football in staging this boycott to highlight the urgent need for social media companies to do more in eliminating racial hatred.
"We will not stop challenging social media companies and want to see significant improvements in their policies and processes to tackle online discriminatory abuse on their platforms."
Championship (second-tier) sides Birmingham City and Swansea City and Scottish champions Rangers recently held week-long boycotts following a spate of racial attacks on their players.
Former Arsenal striker Thierry Henry said last month he was removing himself from social media because of racism and bullying, while Liverpool captain Jordan Henderson has handed over control of his accounts to an anti-cyberbullying charity.
In February, English football bodies sent an open letter to Facebook and Twitter, urging blocking and swift takedowns of offensive posts, as well as an improved verification process for users.
Alex Winston contributed to this report.